评估尾切除术作为免疫检查点抑制剂相关肠球炎的潜在风险因素
Nira A Krasnow1, Donald F Chute2, Ayo S Falade3
1Harvard Medical School, Boston, MA 02115, USA.
Immunotherapy
|June 9, 2023
概括
以前的尾切除似乎不会增加患免疫检查点抑制剂 (ICI) 肠球炎的风险. 这项研究发现尾切除术和ICI诱导的胃肠道副作用之间没有显著的关联.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 是关键的癌症疗法.
- ICI诱导的肠球炎是一个显著的不良事件.
- 前尾切除术在ICI肠球炎中的作用尚不清楚.
研究的目的:
- 为了研究尾切除术和免疫检查点抑制剂 (ICI) 肠球炎之间的关联.
- 为了确定尾切除病史是否会影响患ICI肠球炎的风险.
主要方法:
- 对10907名开始ICI的患者进行了回顾性队列研究 (2010年7月至2020年9月).
- 暴露组:380名先前进行尾切除的患者.
- 对照组:3602名患者的尾正常.
- 通过归因于ICI的组织病理学证据定义的ICI肠道炎.
- 多变量逻辑回归分析用于描述关联.
主要成果:
- 248名患者 (6.2%) 患有ICI肠球炎.
- 在先前尾切除的患者中,ICI肠球炎的调整后几率比为0.82 (95% CI:0.49-1.36;p=0.449).
- 在尾切除和对照组之间没有观察到ICI肠球炎发病率的统计学上显著差异.
结论:
- 之前的尾切除术与患免疫检查点抑制剂肠球炎的风险增加无关.
- 这些发现表明,在评估ICI相关的胃肠道毒性风险时,尾切除病史不需要成为主要考虑因素.
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