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骨特异性性酸酶可以是2型糖尿病中血管化的标志物吗?

Nishant Raizada¹, Mohammad Aslam¹, B K Mishra¹

¹Department of Endocrinology, Centre for Diabetes Endocrinology and Metabolism University College of Medical Sciences (University of Delhi) and GTB Hospital, Dilshad Garden, Delhi, India.

Indian journal of endocrinology and metabolism

|June 9, 2023

概括

在2型糖尿病 (T2DM) 中,不明原因的高酸酶 (ALP) 可能源于骨特异性酸酶 (BAP) 的升高. 较高的BAP水平与血管化标志物相关,表明风险增加.

科学领域:

内分泌学在内分泌学.
心血管医学心血管医学
生物化学生物化学

背景情况:

性酸酶 (ALP) 与血管化有关.
在2型糖尿病患者 (T2DM) 中观察到血清ALP无法解释的升高.
骨特异性性酸酶 (BAP) 在T2DM相关的血管化中的作用尚不清楚.

研究的目的:

在T2DM患者中评估骨特异性性酸酶 (BAP) 水平,患者有不明原因的高ALP.
调查T2DM中BAP和血管化标志物之间的关联.

主要方法:

研究了T2DM患者的不明原因高ALP与T2DM患者的正常ALP.
测量了血清BAP,瘦素,fetuin-A和维生素K2的水平.
评估的脚-手臂指数 (ABI) 作为血管功能的衡量标准.

主要成果:

在T2DM患者中,血清BAP水平显著更高,患有不明原因的高ALP.
BAP与血清 fetuin-A 和维生素 K2 有积极的相关性.
没有发现BAP和瘦素之间的相关性;ABI在各组之间是相似的.

结论:

在T2DM中无法解释的ALP升高可能归因于增加的BAP.
升高的BAP与血管化的标志物有关,表明风险增加.
对BAP在T2DM血管并发症中的作用进行进一步的研究是有必要的.

关键词:

性酸酶是一种性酸酶.特定于骨的性酸酶.胎儿 - 一个勒普丁是一种素.血管化血管化维生素K2 维生素K2 是一种维生素.

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