缺铁是由于缺铁导致的吗?
Vivienne Theobald1,2, Ekkehard Grünig1,2, Nicola Benjamin1,2
1Center for Pulmonary Hypertension Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital Heidelberg Germany.
Pulmonary circulation
|June 9, 2023
概括
肺动脉高血压 (PAH) 患者常见缺铁,但无论BMPR2基因变异,肝素调节仍然正常. 这项研究发现,铁平衡在PAH中很大程度上独立于BMPR2.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 血液学 血液学 血液学
背景情况:
- 异常性和遗传性肺动脉高血压 (I/HPAH) 经常伴有缺铁.
- 铁调节激素赫普西丁受BMP/SMAD信号的影响,包括BMPR-II,这是一种在HPAH中具有常见病原性变异的基因.
- 在I/HPAH患者中,BMPR2变异对肝素水平的影响以前没有被研究过.
研究的目的:
- 为了研究I/HPAH患者的铁代谢和肝素调节,有或没有BMPR2致病变体.
- 为了比较I/HPAH患者组和健康对照组之间的肝素水平和铁状况.
主要方法:
- 一项涉及109名参与者的横截面研究 (23名BMPR2变体携带者,56名BMPR2非携带者,30名健康对照).
- 使用酶相关免疫吸收试验量化血清肝素水平.
- 测量铁状况,炎症标志物 (IL6),红蛋白,BMP2,BMP6和BMPR-II (蛋白质和mRNA) 的测量.
主要成果:
- 在I/HPAH患者中观察到铁缺乏症的高患病率 (84%),需要补充铁.
- 在I/HPAH患者 (有或没有BMPR2变体) 和健康对照人群之间,没有发现肝素水平的显著差异.
- 肝素水平与缺铁程度相关,而不是IL6,红素,BMP2或BMP6水平.
- BMPR2变异状态没有影响肝素水平或铁调节.
结论:
- 在I/HPAH患者中,铁平衡和肝素调节通常保持不变,不管BMPR2的致病变体如何.
- 在I/HPAH中,缺铁的高患病率并不是由于肝素的失调.
- 这些发现表明I/HPAH患者的铁调节在生理上是正常的,独立于BMPR2基因状态.
相关概念视频
Disorders of Erythrocytes
1.0K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
1.0K
Vitamins
826
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
826
The Periodic Table and Organismal Elements
180.2K
Overview
180.2K
Minerals
365
Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
Major...
Major...
365
Disorders of Hemostasis
1.0K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.0K
Immunodeficiency Diseases
1.0K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.0K


