在腹腔大动脉动脉瘤中,专门的亲溶解脂质介质及其受体的性别差异
Amanda C Filiberto1, Victoria Leroy1, Zachary Ladd1
1Department of Surgery, University of Florida, Gainesville, FL.
JVS-vascular science
|June 9, 2023
概括
专门的亲溶解脂质调解剂 (SPMs) 在腹腔大动脉瘤 (AAA) 发育中显示出性别特异性差异. 这些发现凸显了SPM信号在AAA病变发生过程中的作用,对男性和女性的影响不同.
科学领域:
- 心血管研究研究心血管研究
- 脂质媒介生物学的生物学
- 炎症的分辨率 炎症的分辨率
背景情况:
- 腹腔大动脉动脉瘤 (AAA) 是一种危及生命的疾病,其发病因子的性别特异性差异不太清楚.
- 专门的亲溶解脂质调解剂 (SPMs) 对于解决炎症至关重要,但它们在AAA中的作用和潜在的性别特异性影响仍然不清楚.
研究的目的:
- 调查一种假设,即内源性SPM,特别是Resolvin D1 (RvD1),Resolvin D2 (RvD2) 和Maresin 1 (MaR1),以性别特定的方式影响AAA形成和进展.
- 检查SPM及其受体在人类AAA组织和小鼠AAA模型中的表达.
主要方法:
- 在人类和小鼠大动脉组织中量化SPM和omega-3脂肪酸 (DHA,EPA) 水平,使用液体染色学-并联质谱法.
- 通过实时聚合酶链反应测量SPM受体 (FPR2, LGR6, GPR18) 的mRNA表达.
- 统计分析包括学生t测试,曼-惠特尼U测试,以及随时后的Tukey测试的单向ANOVA.
主要成果:
- 与对照人群相比,人类AAA组织显示RvD1水平降低,男性FPR2和LGR6受体下调.
- 在小鼠AAA模型中,男性和女性的RvD2和MaR1水平较高,以及DHA和EPA的增加.
- 与雄性相比,在经过弹性酶治疗的雌性小鼠中,FPR2表达升高.
结论:
- 在AAA的背景下,SPM及其相关的G蛋白结合受体的表达存在显著的基于性别的差异.
- 由SPM介导的信号通路与AAA病变发生过程中观察到的性别差异有关.
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