瘤-中性粒细胞交叉声促进了瘤与中性粒细胞的交叉声
Dominique S Rubenich1, Priscila O de Souza1, Natalia Omizzollo1
1Programa de Pós-Graduação em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil.
Frontiers in immunology
|June 9, 2023
概括
质母细胞瘤细胞重新编程中性粒细胞以促进瘤生长并创造一种免疫抑制的环境. 这种中性粒细胞重编程与患者预后不佳有关,并建议新的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 质母细胞瘤 (GB) 中的瘤微环境 (TME) 具有阻碍抗瘤免疫力的免疫抑制细胞.
- 中性粒细胞在瘤进展中的作用是有争议的,有证据表明在TME内具有双重功能.
研究的目的:
- 研究中性粒细胞在质母细胞瘤进展中的作用.
- 阐明质母细胞瘤-中性粒细胞通信的机制及其对TME的影响.
主要方法:
- 在体外和体内测试被用来研究质母细胞瘤与中性粒细胞相互作用.
- 使用了先进的3D瘤模型和Balb/c裸体小鼠.
- 对瘤能量代谢,细胞因子概况和中性粒细胞外细胞陷 (NETs) 形成的分析.
主要成果:
- 质母细胞瘤和中性粒细胞之间的双向通信已被证明,促进了免疫抑制的TME.
- 中性粒细胞参与瘤恶性瘤是时间和度依赖的.
- 在GB患者中确定了一种影响TME分泌体的线粒体不匹配,以及一种亲中性粒细胞招募细胞因子环境.
- 质瘤-中性粒细胞交叉连接通过NETs维持瘤激活,涉及NFκB信号传递.
- 临床数据将中性粒细胞-淋巴细胞比率 (NLR),IL-1β和IL-10与质母细胞瘤的不良结果联系起来.
结论:
- 中性粒细胞被质母细胞瘤重新编程以促进瘤的进展.
- 了解质瘤-中性粒细胞交叉对理解瘤进展和免疫细胞参与至关重要.
- 研究结果表明,潜在的治疗策略是针对质细胞瘤中介性免疫抑制.
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