"训练有素的免疫力"来自于"训练有素的免疫力".
Samer Singh1, Dhiraj Kishore2, Rakesh K Singh3
1Centre of Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Frontiers in immunology
|June 9, 2023
概括
儿童BCG疫苗接种可以预防白血病. 暴露于Mycobacterium spp. 的情况. 在接种疫苗的儿童中与较低的白血病发病率相关,这表明受过训练的免疫力发挥了作用.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科瘤学 儿科瘤学
- 流行病学 流行病学
背景情况:
- 儿童白血病发病率 (LI) 的预防因素在很大程度上是未知的.
- 关于儿童接种疫苗的先前研究,特别是BCG,作为对LI的保护,产生了相互矛盾的结果.
- 缺乏一个统一的框架来解释过去研究中的可变结果.
研究的目的:
- 调查儿童疫苗接种覆盖率与欧洲国家儿童早期白血病发病率之间的关系.
- 探索BCG疫苗接种和Mycobacterium spp.的潜在保护作用. 儿童时期的暴露 LI.
- 在儿童白血病的背景下检查训练免疫力的影响.
主要方法:
- 分析2020年关于幼儿期LI和儿童疫苗接种覆盖率的欧洲数据.
- 在BCG疫苗接种和未接种人群中的LI与Mycobacterium spp.之间的相关性分析. 暴露 (结核素免疫活性).
- 检查LI与其他疫苗 (MCV2,PCV3,DTP3) 之间的关联.
主要成果:
- 在0-4岁儿童中,在BCG覆盖率>90%的国家和结核素免疫反活性 (r(24) 的LI之间观察到强烈的负相关性: -0.7868,p值:<0.0001).
- 在未接种疫苗的人群中,没有发现LI的显著相关性,尽管在其他疫苗中发现了弱相关性.
- BCG疫苗接种覆盖率显示,与Mycobacterium spp.的共变是负的. 在接种疫苗的儿童中暴露.
结论:
- 早期儿童BCG疫苗接种,可能被Mycobacterium spp.增强. 暴露,可以通过训练有素的免疫力来保护儿童白血病.
- 训练免疫的概念可能解释了BCG和儿童LI之前研究中的差异.
- 需要在高负担国家进行进一步的研究,控制受过训练的免疫力和混因子,以确认BCG疫苗在预防儿童LI中的作用.
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