相关实验视频
Updated: Jul 27, 2025

12:08
Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
18.9K
使用胰岛素降解剂/胰岛素亚斯帕特的实用指南:马来西亚的多学科方法
Siew Pheng Chan1, Malik Mumtaz2, Jeyakantha Ratnasingam3
1MBBS (Mal) FRCP (Edin), AM (Mal), Consultant Endocrinologist, University of Malaya, Jln Profesor Diraja Ungku Aziz, Kuala Lumpur, Selangor, Malaysia.
概括
胰岛素降糖/胰岛素亚斯巴特 (IDegAsp) 提供基底和食时间的葡萄糖控制在一个注射,显示优越或非劣质的疗效与较少的低血糖. 马来西亚专家提供了关于其在2型糖尿病管理中的使用的见解.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 胰岛素降解剂/胰岛素亚斯巴特 (IDegAsp) 是一种用于基础和饭时血糖控制的联合配方.
- 与现有胰岛素疗法相比,它显示出优越或非劣质的降血糖功效.
- IDegAsp与整体和夜间低血糖症的降低率有关.
研究的目的:
- 为马来西亚专家小组提供关于IDegAsp使用的见解.
- 引导IDegAsp在各种2型糖尿病患者群体中的使用.
- 针对涉及IDegAsp.的治疗强化策略.
主要方法:
- 专家小组就IDegAsp在2型糖尿病中的使用达成共识.
- 建议开始使用IDegAsp,主要是每天一次给药,主要是吃饭.
- 关于剂量调整,强化至每天两次剂量和斋月期间管理的指导.
主要成果:
- IDegAsp可以每天启动一次,根据患者的反应每周进行调整.
- 建议在患有心脏或脏并发症的患者使用较低的初始剂量.
- 每天两次服用IDegAsp的剂量应根据食中的碳水化合物含量进行调整,而不是固定50:50的比例.
结论:
- IDegAsp为各种2型糖尿病患者配置文件提供了灵活的治疗选择.
- 建议在斋月之前提前切换到IDegAsp,以获得更好的血糖控制.
- 患者对碳水化合物摄入的教育对于有效的IDegAsp治疗至关重要.
相关概念视频
Insulin Formulations: Types and Delivery
238
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
Short-acting insulins are divided into...
238
Insulin: Dosing Regimen and Adverse Effects
216
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
216
Diabetes: Management and Pharmacotherapy
319
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
319
Insulin: Biosynthesis, Chemistry, and Preparation
443
The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
443
Diabetes Mellitus: Type 2 and Gestational
2.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
Oral Hypoglycemic Agents: Glinides
190
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
190

