相关实验视频
Updated: Jul 27, 2025

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An in vivo Assay to Test Blood Vessel Permeability
Published on: March 16, 2013
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在这里,在这里,在这里
1Faculty of Pharmacy, Middle East University, Amman, Jordan.
Saudi journal of biological sciences
|June 9, 2023
概括
来自Quercus coccifera叶的甲醇提取物显示出显著的抗糖尿病潜力,有效降低小鼠的血糖. 这种树叶提取物也显示出对肝脏和脏的保护作用.
科学领域:
- 药理学和民族植物学
- 自然产品化学 自然产品化学
背景情况:
- 来自Fagaceae家族的树物种 (Quercus) 在地中海地区普遍存在.
- 传统医学利用各种树物种来治疗糖尿病等疾病.
研究的目的:
- 为了评估Quercus coccifera叶子提取物的抗糖尿病活性.
- 研究不同提取物的植物化学特征,毒性和疗效.
主要方法:
- 提取Q. coccifera的叶子使用溶剂,如n-hexane,,和甲醇.
- 在体外测定α-氨酶和α-葡萄糖酶抑制.
- 使用糖尿病小鼠模型进行体内研究,以评估血糖水平和毒性.
主要成果:
- 甲醇提取物在体外表现出强烈的α-氨基酶 (IC50:0.17μg/ml) 和α-葡萄糖酶 (IC50:0.38μg/ml) 的抑制,超过了阳性对照acarbose.
- 在体内,每天200毫克/公斤的甲醇提取物显著降低了糖尿病小鼠的血糖 (146.8毫克/分升),没有任何不良影响.
- 其他提取物显示中度至低的抗糖尿病活性,有一些肝脏和脏毒性的迹象.
结论:
- 甲醇Q. coccifera叶片提取物显示出控制高血糖的显著潜力.
- 提取物具有脏和肝脏的保护性质,这表明它对糖尿病管理的治疗价值.
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