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Updated: Jul 27, 2025

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Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

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通过通过线粒体介导的亡的抗扩散和诱导

Kanokkorn Vichitsakul1, Khanittha Laowichuwakonnukul1, Boonchoy Soontornworajit2,3

  • 1Division of Biochemistry, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathumthani, 12120, Thailand.

Heliyon
|June 9, 2023
PubMed
概括

含有甘酸 (GA) 的Garcinia hanburyi树脂 (GHR) 通过诱导亡,有效抑制结肠直肠癌 (CRC) 细胞的增殖. GHR对CRC细胞具有很高的选择性,对正常细胞的毒性最小,表明其作为CRC治疗的潜力.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.结肠直肠癌是一种癌症.甘博基酸是甘博基酸的一种酸.加西尼亚汉布里伊 (Garcinia hanburyi) 是一种

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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