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异黄和益生菌对大鼠骨和骨细胞的影响
Iskandar Azmy Harahap1, Maciej Kuligowski2, Marcin Schmidt3
1Department of Human Nutrition and Dietetics, Faculty of Food Science and Nutrition, Poznań University of Life Sciences, Poznań, Poland.
异黄和益生菌如Lactobacillus acidophilus可能通过增加大鼠的骨和骨质母细胞数量来改善骨健康. 然而,这些补充剂之间没有观察到任何联合益处.
科学领域:
- 营养生物化学 营养生物化学
- 骨生理学 骨生理学
- 微生物学 微生物学
背景情况:
- 异黄和益生菌显示出调节吸收和骨代谢的潜力.
- 了解它们的单独和综合作用对于骨健康干预至关重要.
研究的目的:
- 为了研究异黄 (戴兹,基因斯坦) 和益生菌 (Lactobacillus acidophilus) 对雌性大鼠的状况和骨健康的影响.
- 评估结合异黄和益生菌的潜在协同效应.
主要方法:
- 成年雌性Wistar大鼠被分配到对照组或治疗组 (大豆,异黄,L. acidophilus或组合).
- 评估了血清生物化学参数,组织含量,骨质母细胞/骨细胞计数和骨髓脂肪细胞百分比.
- 骨组织的组织学分析是使用血素和欧染色进行的.
主要成果:
- L. acidophilus补充剂显著增加了大腿骨含量.
- 异黄 (戴兹,基尼斯) 显著增加了骨质细胞和骨质细胞的数量.
- 用异黄,L. acidophilus或它们的组合补充剂减少了心脏和脏中的沉积.
- 在脏含量和骨质细胞数量之间发现了反向相关性.
结论:
- 单独给予异黄或L. acidophilus,有望改善大鼠骨健康标志物.
- 戴兹,基因斯坦和L. acidophilus的组合可能会增强骨和细胞群.
- 在这项研究中,异黄和益生菌之间没有检测到协同效应.
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