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High Precision FRET at Single-molecule Level for Biomolecule Structure Determination
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可视化三异体N-甲基-D-阿斯巴酸受体子单元组成.

Stephen Beesley1, Akash Gunjan1, Sanjay S Kumar1

  • 1Department of Biomedical Sciences, College of Medicine and Program in Neuroscience, Florida State University, Tallahassee, FL, United States.

Frontiers in synaptic neuroscience
|June 9, 2023
PubMed
概括

研究人员使用先进显微镜可视化了突触中的N-甲基-D-酸盐受体 (NMDAR) 子单元组成. 这证实了三异体NMDARs,并提供了关于神经退行性疾病脆弱性的见解.

关键词:
在 GluN3 的情况下,GluN3它们是NMDA受体.同焦点显微镜的共焦显微镜.免疫组织化学 免疫组织化学分单位组合的组成.t-NMDARs 是一个NMDAR.可视化子单元组合的构成.

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相关概念视频

¹H NMR: Complex Splitting01:13

¹H NMR: Complex Splitting

A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied first.