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在生物组织中检测点光体的双比方法

Giles Blaney¹, Fernando Ivich², Angelo Sassarolia¹

¹Tufts University, Department of Biomedical Engineering, Medford, MA USA, 02155.

|June 9, 2023

概括

双比 (DR) 近红外扩散体内流动细胞计 (DiFC) 增强信号对噪声比 (SNR),用于更深层组织成像. 这种技术有望改善循环细胞的检测,前提是噪声是可控的,自光是表面加权的.

科学领域:

生物光子学生物光子学
医疗成像医学成像
光学传感传感器是什么?

背景情况:

扩散体内流动细胞计 (DiFC) 是一种新兴的技术,用于标记循环细胞的非侵入性检测.
目前的DiFC方法在测量深度上面临限制,原因是信号与噪声比率 (SNR) 较低,主要是由背景组织自光引起的.

结论:

在体外应用中,DR DiFC显示了改善循环细胞检测深度和SNR的潜力.
成功实施取决于设计DR-取消噪声 (例如,通过源复合),并确认生物组织中表面加权的自光分布.

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