Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Wald-Wolfowitz Runs Test I01:17

Wald-Wolfowitz Runs Test I

685
The Wald-Wolfowitz test, also known as the runs test, is a nonparametric statistical test used to assess the randomness of a sequence of two different types of elements (e.g., positive/negative values, successes/failures). It examines whether the order of the elements in a sequence is random or if there is a pattern or trend present. This nonparametric test applies to any ordered data despite the population and sample data distribution, even if a higher sample size is available.
The test works...
685
Wald-Wolfowitz Runs Test II01:17

Wald-Wolfowitz Runs Test II

279
The Wald-Wolfowitz runs test, commonly referred to as the runs test, is a nonparametric test used to assess the randomness of ordered data. The test evaluates the number of runs, which are consecutive sequences of similar elements within the data. If the number of runs is significantly higher or lower than expected, the data is considered non-random, indicating a detectable pattern or structure.
For binary data, runs are identified using symbols such as + and −, or equivalently, 1s and...
279
Per-Unit Sequence Models01:26

Per-Unit Sequence Models

101
An ideal Y-Y transformer, grounded through neutral impedances, displays per-unit sequence networks akin to those of a single-phase ideal transformer when subjected to balanced positive- or negative-sequence currents. These currents do not produce neutral currents, and their associated voltage drops.
Zero-sequence currents, which are identical in magnitude and phase, generate a neutral current, resulting in voltage drops across the neutral impedance and the low-voltage winding. If the...
101
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.9K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.9K
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

11.3K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
11.3K
Genetic Drift03:33

Genetic Drift

40.1K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
40.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Sequence basis of transcription initiation in the human genome.

Science (New York, N.Y.)·2024
Same author

Sequence basis of transcription initiation in human genome.

bioRxiv : the preprint server for biology·2023
Same author

Fast and efficient fully 3D PET image reconstruction using sparse system matrix factorization with GPU acceleration.

Physics in medicine and biology·2011
Same author

Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin β1 complex in the progression of hepatocellular carcinoma.

PloS one·2011
Same author

Detailed assessment of isotope ratio infrared spectroscopy and isotope ratio mass spectrometry for the stable isotope analysis of plant and soil waters.

Rapid communications in mass spectrometry : RCM·2011
Same author

[Enhancement of osteoblastic differentiation of bone marrow mesenchymal stem cells in rats by sinusoidal electromagnetic fields].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi·2011

相关实验视频

Updated: Jul 27, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.1K

迪里克莱特扩散得分模型用于生物序列生成

Pavel Avdeyev1, Chenlai Shi1, Yuhao Tan1

  • 1Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, USA.

ArXiv
|June 9, 2023
PubMed
概括
此摘要是机器生成的。

这项研究引入了一种新的迪里克莱特扩散得分模型,用于生成离散的生物序列. 该模型有效地设计DNA序列,并解决复杂的约束问题,如Sudoku.

科学领域:

  • 计算生物学 计算生物学
  • 机器学习 机器学习

更多相关视频

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
09:14

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Published on: June 28, 2018

7.2K
Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy
12:15

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

8.8K

相关实验视频

Last Updated: Jul 27, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.1K
Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
09:14

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Published on: June 28, 2018

7.2K
Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy
12:15

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

8.8K
  • 生物信息学是一种生物信息学.
  • 背景情况:

    • 深度生成模型对于设计具有复杂约束的生物序列至关重要.
    • 基于随机微分方程 (SDEs) 的现有扩散模型本质上不适合像DNA序列这样的离散数据.
    • 需要一种新的方法来适应连续扩散模型用于离散序列生成.

    结论:

    • 迪里克莱特扩散分数模型为涉及离散数据的生成任务提供了一个强大的新框架.
    • 这种方法弥合了连续扩散模型和离散序列设计之间的差距.
    • 该模型对合成生物学和生物信息学 (包括DNA序列设计) 的应用非常有希望.