基底前脑连接在新皮层的多模式梯度
bioRxiv : the preprint server for biology
|June 9, 2023
概括
基底前脑 (BF) 中的胆协神经元显示出各种各样的分支模式. 这种复杂性影响了它们的结构连接如何与大脑皮层中的功能性大脑网络保持一致.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 神经解剖学是一个神经解剖学.
背景情况:
- 大脑皮层的胆固醇内尔化源于基底前脑 (BF).
- 上升的BF胆性投射高度分支,准多个皮质区域.
- 结构组织与BF预测的功能整合之间的关系尚不清楚.
研究的目的:
- 为了研究基底前脑 (BF) 与皮质的胆固醇连接的多式梯度在人类中.
- 确定BF投影的结构组织是否反映了与皮层目标的功能整合.
- 探索BF胆固醇神经元之间的轴突树木复杂性的变化.
主要方法:
- 高分辨率的7T扩散和休息状态功能性MRI在人类.
- 人类[18F]甲-二沙米 (FEOBV) PET成像.
- 在小鼠中进行级病毒追踪和[18F]FEOBV PET.
主要成果:
- 观察到结构功能连接连接的渐变从前中向后侧BF下降,在Meynert (NbM) 的基底核中最明显.
- 这种梯度的皮质表达表明,从单模向跨模区域的连接减少,在中环岛皮质中最低.
- 较高的皮层胆能内置与较低的BF结构功能连接性联系相关,表明扩散的轴突树木化.
- 鼠标模型证实了BF胆固醇神经元中轴突树木化的梯度,复杂的分支向环状岛屿区域投射.
结论:
- BF胆能神经元表现出轴突树木化复杂性的梯度.
- 亚种群在功能整合与皮层目标的模块化与扩散性方面有所不同.
- 研究结果揭示了BF胆能系统组织的原理及其在皮质功能网络中的作用.
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