Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

67
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
67

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Self-collected biospecimen consent and return rates in a population-based study among women with ovarian cancer: insights from the ORCHiD study.

Cancer causes & control : CCC·2026
Same author

Vaginal Microbiome Composition, Diversity and Dysbiosis: The ORCHiD Study.

Research square·2025
Same author

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.

Nature communications·2024
Same author

Hepatic bile acid accretion correlates with cholestatic liver injury and therapeutic response in <i>Cyp2c70</i> knockout mice with a humanized bile acid composition.

American journal of physiology. Gastrointestinal and liver physiology·2024
Same author

Microsecond dynamics control the HIV-1 Envelope conformation.

Science advances·2024
Same author

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.

bioRxiv : the preprint server for biology·2024
Same journal

Whole-Embryo 3D Quantification Reveals Conserved Topological Design and Scaling of Germ Layers in Xenopus.

bioRxiv : the preprint server for biology·2026
Same journal

scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation.

bioRxiv : the preprint server for biology·2026
Same journal

M1C IS NECESSARY FOR DARAXONRASIB RESISTANCE OF NSCLC KRAS(G12C) MUTANT CELLS.

bioRxiv : the preprint server for biology·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
查看所有相关文章

相关实验视频

Updated: Jul 27, 2025

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
07:10

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay

Published on: September 14, 2014

14.4K

微秒动态控制了HIV-1包裹形状的控制.

Ashley L Bennett1, R J Edwards1, Irina Kosheleva2

  • 1Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.

bioRxiv : the preprint server for biology
|June 9, 2023
PubMed
概括
此摘要是机器生成的。

研究人员观察到HIV-1信封 (Env) 糖蛋白的快速微秒级结构变化,在打开之前揭示了一个关键的中间状态. 这一发现表明,通过针对这些早期过渡,设计有效的艾滋病毒疫苗的新策略.

科学领域:

  • 结构生物学是结构生物学.

更多相关视频

Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers
11:45

Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers

Published on: March 8, 2012

12.3K
Determination of Molecular Structures of HIV Envelope Glycoproteins using Cryo-Electron Tomography and Automated Sub-tomogram Averaging
07:29

Determination of Molecular Structures of HIV Envelope Glycoproteins using Cryo-Electron Tomography and Automated Sub-tomogram Averaging

Published on: December 1, 2011

41.6K

相关实验视频

Last Updated: Jul 27, 2025

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
07:10

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay

Published on: September 14, 2014

14.4K
Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers
11:45

Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers

Published on: March 8, 2012

12.3K
Determination of Molecular Structures of HIV Envelope Glycoproteins using Cryo-Electron Tomography and Automated Sub-tomogram Averaging
07:29

Determination of Molecular Structures of HIV Envelope Glycoproteins using Cryo-Electron Tomography and Automated Sub-tomogram Averaging

Published on: December 1, 2011

41.6K
  • 病毒学 病毒学
  • 生物物理学的生物物理.

    • 背景情况:

    • 人类免疫缺陷病毒1型 (HIV-1) 包裹 (Env) 糖蛋白通过在受体结合时发生显著的形状变化来调解病毒的进入.
    • 了解Env的动态结构转变对于开发有效的疫苗和治疗方法至关重要.
    • 之前的研究已经描述了毫秒时间尺度事件,但更快的微秒时间尺度动力学仍然在很大程度上未被探索.

    结论:

    • 艾滋病毒-1 Env ectodomain 的快速动态,特别是在三元顶循环中,代表了一个关键的中间状态.
    • 设计了一种Env结构来稳定顶端环接触,改变抗体结合方向.
    • 阻止这些早期中间状态提供了一个有前途的策略,用于诱导艾滋病毒疫苗接种广泛中和抗体.