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Updated: Jul 27, 2025

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维持年龄的人类神经元显示出内在神经元生长能力的发育性损失

Bo P Lear, Elizabeth A N Thompson, Kendra Rodriguez

    bioRxiv : the preprint server for biology
    |June 9, 2023
    PubMed
    概括

    直接重新编程的人类神经元显示神经元随着年龄的增长而减少,反映了在动物中观察到的发育开关. 这表明表观遗传变化对人类中枢神经系统 (CNS) 轴突再生潜力产生影响.

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    In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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