在皮层的微管,反对在actomyosin驱动的膜入口期间的皮层微管
Alyssa R Quiogue1, Eisuke Sumiyoshi1, Adam Fries1,2
1Institute of Molecular Biology.
bioRxiv : the preprint server for biology
|June 9, 2023
概括
微管稳定性,由CLS-2和KNL-1和BUB-1等kinetochore蛋白调节,对于C. elegans卵细胞半转化I至关重要. 这种稳定性限制了膜的进入,使得合适的收缩环组装和极体挤出成为可能.
科学领域:
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
- 分子生物学分子生物学
背景情况:
- 在C. elegans卵细胞半转化I过程中,一个收缩环聚集在一个更大的皮质actomyosin网络中.
- 这个网络调解环形动力学,并在极体挤出过程中控制膜进入.
- CLS-2是一种微管稳定蛋白,此前曾被提议用于平衡actomyosin张力和微管性,用于环组装.
结论:
- 作为一个kinetochore子综合体的一部分,CLS-2稳定了微管,使卵细胞皮层变硬.
- 这种皮层硬化限制了整个膜入口,这对收缩环功能至关重要.
- 介质变化I期间成功的极体挤出依赖于这种微管介导的刚性和actomyosin动态的平衡.
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