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Updated: Jul 27, 2025

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays
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对先天脊髓再生的单细胞分析确定了神经元修复的交叉模式

Vishnu Muraleedharan Saraswathy, Lili Zhou, Mayssa H Mokalled

    bioRxiv : the preprint server for biology
    |June 9, 2023
    PubMed
    概括

    成年斑马鱼通过神经发生和神经元可塑性再生脊髓. 受伤反应神经元 (iNeurons) 是这种修复的关键,利用囊泡运输进行功能恢复.

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    Neurogenesis and Regeneration of Nervous Tissue01:15

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    In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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