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Updated: Aug 16, 2026

Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts
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Published on: February 5, 2018

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通过人类3D直接神经元重编程对阿尔茨海默病神经病理的内源复述

Zhao Sun, Ji-Sun Kwon, Yudong Ren

    bioRxiv : the preprint server for biology
    |June 9, 2023
    PubMed
    概括

    研究人员使用患者细胞创建了阿尔茨海默病 (AD) 模型. 这些模型模仿AD病理,并表明早期使用分泌酶抑制剂或RTE抑制剂的治疗可以减少疾病的进展.

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    Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
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    Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...