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Updated: Jul 27, 2025

Reverse Genetics to Engineer Positive-Sense RNA Virus Variants
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Reverse Genetics to Engineer Positive-Sense RNA Virus Variants

Published on: June 9, 2022

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新型SARS-CoV-2变种的快速克隆无变异发生,使用一种新的逆转基因平台

Enja Kipfer1, David Hauser1, Martin J Lett1

  • 1Molecular Virology, Department of Biomedicine, University of Basel, Petersplatz 10, 4009 Basel, Switzerland.

bioRxiv : the preprint server for biology
|June 9, 2023
PubMed
概括

一个新的无克隆系统 (CLEVER) 能够快速设计RNA病毒基因组,包括SARS-CoV-2. 这种反向遗传学平台加速了对病毒变体和其他加链RNA病毒的研究.

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相关概念视频

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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