在初级渐进性失言症的logopenic变体中的网络解剖学
medRxiv : the preprint server for health sciences
|June 9, 2023
概括
逻辑变异性初级渐进性失语症 (lvPPA) 脑缩开始于特定区域,并通过不同的网络传播. 健康大脑中的网络连接预测了lvPPA的进展,为疾病异质性提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 神经成像是一种神经成像.
背景情况:
- 逻辑变异性初级渐进性失言症 (lvPPA) 是一种神经退行性综合征,导致语言逐渐衰退.
- 了解最初受影响的大脑区域 (中心) 和传播模式对于理解lvPPA至关重要.
- 确定疾病特异性网络可能会揭示临床异质性背后的机制.
研究的目的:
- 为了确定lvPPA的最初的皮层目标 (中心).
- 为了调查缩是否通过预定义的大脑网络传播.
- 为了确定功能连接是否预测lvPPA中的缩传播.
主要方法:
- 使用了来自lvPPA患者的横截面结构MRI数据.
- 使用基于表面的分析和HCP-MMP1.0地图书来定义疾病中心.
- 结合了对照组的功能性MRI数据和lvPPA患者的纵向MRI数据,以导出网络并评估连接性对缩传播的预测能力.
主要成果:
- 确定了两个不同的大脑网络,定在左前角和后上旋转中,与lvPPA的重复和命名缺陷有关.
- 在健康个体中,这些网络中的连接强度显著预测了lvPPA患者的纵向缩进展.
- 在lvPPA中,缩的进展起源于下面的头顶和顶-头顶结合区域.
结论:
- lvPPA的进展至少遵循两个部分不同的途径,起源于特定的皮质区域.
- 健康大脑中的功能连接模式可以预测lvPPA中神经退行的轨迹.
- 这些发现有助于理解lvPPA的异质临床表现和预后.
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