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Updated: Jul 27, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Published on: September 13, 2018

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p120 RasGAP和ZO-2对于Hippo信号和瘤抑制功能至关重要,这些功能由p190A RhoGAP介导

Hanyue Ouyang, Wangji Li, Steen H Hansen

    bioRxiv : the preprint server for biology
    |June 9, 2023
    PubMed
    概括

    p190A RhoGAP (ARHGAP35) 通过与RasGAP和ZO-2相互作用,以激活Hippo通路,抑制细胞增殖和抑制瘤,充当瘤抑制剂. 低ARHGAP35表达与特定患者群体的生存率下降相关.

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