富士P2阳性神经元的活动与头乞讨行为有关
Sarah C Ludington1, Jordan E McKinney1, Julie M Butler1
1Department of Biology, Stanford University, Stanford, CA 94305, USA.
bioRxiv : the preprint server for biology
|June 9, 2023
概括
转录因子FoxP2在青头大脑中广泛分布. 富士P2阳性神经元在乞讨和侵略等社会行为中表现出增加的活动.
科学领域:
- 神经科学是一个神经科学.
- 行为生态学 行为生态学
- 进化生物学 进化生物学
背景情况:
- 运动功能对于各种物种的社会行为至关重要.
- 转录因子FoxP2以其在语音通信中的作用而闻名,但其更广泛的社会行为功能不太了解.
- 在非模型生物体中研究FoxP2可以揭示社会行为中的保留角色.
研究的目的:
- 为了检查毒头 (Ranitomeya imitator) 的大脑中FoxP2的分布和神经元活动.
- 测试与对照状态相比,在特定的社会行为 (乞讨,侵略) 中,FoxP2-阳性神经元是否表现出差异性活动.
- 探索FoxP2在陆地脊椎动物的发声之外的社会行为中的潜在的概括性作用.
主要方法:
- 免疫组织化学被用来绘制头大脑中FoxP2-阳性神经元的分布.
- 通过测量 FoxP2 阳性神经元在乞讨显示,侵略和非社会控制条件中的活动来评估神经元激活.
- 行为背景包括孤立的养育,母卵养 (乞讨展示) 和之间的相互作用 (侵略).
主要成果:
- 狐P2在头大脑中分布广泛,与哺乳动物,鸟类和鱼类中观察到的模式一致.
- 在乞讨显示期间,在条纹体和小脑中观察到FoxP2-阳性神经元激活的增加.
- 在子之间的侵略性遭遇期间,在核 accumbens 中检测到 FoxP2 阳性神经元活动的升高.
结论:
- FoxP2在两动物大脑中得到广泛表达,其神经元活动与不同的社会行为相关.
- 这些发现表明,FoxP2在调节社会行为方面起着保留的作用,可能超出语音沟通范围.
- 这项研究为未来研究FoxP2在脊椎动物社交中的进化和功能意义提供了基础.
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