生物的时钟细胞和昼夜基因表达的生物景观
Ines L Patop1, Ane Martin Anduaga1, Ivana L Bussi2
1Biology Department, Brandeis University, Waltham, MA, 02454, USA.
bioRxiv : the preprint server for biology
|June 9, 2023
概括
大多数细胞缺乏内部的昼夜钟. 相反,节律性基因表达是由颜料分散因子 (PDF) 信号或两者的组合驱动的,揭示了日常节律的新机制.
科学领域:
- 时间生物学 时间生物学
- 分子生物学分子生物学
- 神经科学是一个神经科学.
背景情况:
- 循环节律支配着日常的生理和行为周期.
- 人们普遍认为细胞自主昼夜时钟,但外部调节是可能的.
- 像颜料分散因子 (PDF) 等神经的作用在多索菲拉生物的昼夜节律正在研究中.
结论:
- 在Drosophila中,循环的每日基因表达通过三个不同的机制实现.
- 这些机制包括内源分子钟,PDF信号驱动表达和两者的组合.
- 这项研究重新定义了我们对Drosophila不同细胞类型的昼夜节律生成的理解.
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