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Longitudinal Research

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...

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Updated: Jul 11, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

利用纵向扩散MRI数据来量化白质微结构性衰退在正常和异常衰老中的差异.

Derek B Archer^1,2, Kurt Schilling^3,4, Niranjana Shashikumar¹

¹Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN, USA.

bioRxiv : the preprint server for biology

|June 9, 2023

概括

白质微结构性衰退在衰老中很常见. 特定的通道,比如环带,在异常衰老中比正常衰老更容易受到伤害.

科学领域:

神经成像是一种神经成像.
衰老研究研究衰老研究
神经退行发生神经退行.

更多相关视频

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

相关实验视频

Last Updated: Jul 11, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

背景情况:

研究正常和异常衰老过程之间的白质微结构衰退的差异.
了解大脑衰老的轨迹对于识别神经退行性途径至关重要.

结论:

白质微观结构的衰退在整个衰老谱中发挥着重要作用.
异常衰老不成比例地影响某些白质道,突出显示了未来研究的潜在目标.
需要进一步的大规模研究来阐明神经退行性机制.