Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.9K
Line Loss01:10

Line Loss

276
The different configurations of source-load connections include wye (star) and delta connections. The relationship between line and phase voltages and currents varies depending on the configuration. When the source is supplying power, it is transmitted through the wires to the load, and during this transmission, some power is absorbed by the wires, leading to line loss.
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
276
Minor Losses in Pipes01:25

Minor Losses in Pipes

1.1K
In pipe systems, minor losses refer to energy losses arising from components such as valves, bends, fittings, expansions, and other features that disrupt the steady flow of fluid. These disturbances cause energy dissipation through turbulence and resistance, which engineers quantify to manage system efficiency effectively.
Valves play a significant role in generating minor losses by obstructing or redirecting the fluid flow. When a valve is closed or partially closed, it restricts the flow...
1.1K
Loss of Carboxy Group as CO2: Decarboxylation of β-Ketoacids01:02

Loss of Carboxy Group as CO2: Decarboxylation of β-Ketoacids

3.2K
Carboxylic acids, upon heating, undergo a decarboxylation reaction by releasing carbon dioxide gas. Monocarboxylic acids do not undergo decarboxylation easily. However, a silver salt of carboxylic acid reacts with bromine or iodine under high temperature to release carbon dioxide gas and forms halide with one less carbon. This reaction is called the Hunsdiecker reaction.
3.2K
Major Losses in Pipes01:28

Major Losses in Pipes

1.2K
When a fluid flows through a pipe, it experiences energy losses due to frictional resistance along the pipe walls, known as major losses. These energy losses result in a pressure drop, which varies based on the flow conditions — whether laminar or turbulent — and the specific physical properties of the fluid and pipe.
Fluid flow can be classified as laminar or turbulent, primarily based on the Reynolds number. This dimensionless number reflects the relative influence of inertial to...
1.2K
Lossy Lines and Overvoltages01:22

Lossy Lines and Overvoltages

113
Transmission-line series resistance and shunt conductance cause three primary effects: attenuation, distortion, and power losses.
Attenuation
When constant series resistance and shunt conductance are present, voltage and current equations are modified. The propagation constant indicates that voltage and current waves consist of both forward and backward traveling components. These waves attenuate as they propagate, with the attenuation factor related to the resistance and conductance. In a...
113

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Type I Interferon-Driven Monocyte Dysregulation and MAS-associated CD8 <sup>+</sup> T cells During Macrophage Activation Syndrome.

bioRxiv : the preprint server for biology·2026
Same author

Cancer During Pregnancy: Navigating Clinical and Research Challenges.

Current oncology (Toronto, Ont.)·2026
Same author

A pathogenic gut lipoglycan drives systemic thromboinflammation in lupus nephritis.

Annals of the rheumatic diseases·2026
Same author

RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis.

Nature communications·2026
Same author

KRT17 promotes triple negative breast cancer through activation of Wnt signaling and γδ T-cells recruitment.

Communications biology·2026
Same author

Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors.

Nature communications·2025
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
查看所有相关文章

相关实验视频

Updated: Jul 27, 2025

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
08:43

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Published on: June 6, 2016

8.9K

的损失.

Zarina Brune, Dan Li, Su Song

    bioRxiv : the preprint server for biology
    |June 9, 2023
    PubMed
    概括
    此摘要是机器生成的。

    干扰素调节因子5 (IRF5) 的损失预测乳腺癌转移和生存率低下. 恢复IRF5通过增强免疫细胞活性和改变蛋白质合成来抑制瘤生长和扩散.

    更多相关视频

    Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs
    06:58

    Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs

    Published on: May 18, 2022

    1.1K
    Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
    12:06

    Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System

    Published on: May 12, 2011

    20.8K

    相关实验视频

    Last Updated: Jul 27, 2025

    Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
    08:43

    Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

    Published on: June 6, 2016

    8.9K
    Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs
    06:58

    Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs

    Published on: May 18, 2022

    1.1K
    Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
    12:06

    Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System

    Published on: May 12, 2011

    20.8K

    科学领域:

    • 在瘤学瘤学.
    • 分子生物学分子生物学
    • 免疫学 免疫学 免疫学

    背景情况:

    • 乳腺癌仍然是导致死亡的主要原因,需要识别新型转移和生存的预测因素.
    • 干扰素调节因子5 (IRF5) 在乳腺瘤发生中的作用尚不清楚.

    研究的目的:

    • 调查干扰素调节因子5 (IRF5) 在乳腺癌进展,转移和生存中的作用.
    • 阐明IRF5影响乳腺瘤发生的分子机制.

    主要方法:

    • 利用了癌症基因组图谱 (TCGA) 和乳腺瘤发生的小鼠模型.
    • 在乳腺上皮细胞上进行了组织学分析,RNA测序 (RNA-seq) 和ChIP测序 (ChIP-seq).
    • 采用侵袭性乳腺癌模型来评估IRF5再表达的影响.

    主要成果:

    • 认定IRF5功能丧失是转移的预测因素,乳腺癌的存活率降低.
    • 缺少IRF5导致乳腺结构变化,以及光线和肌皮细胞的扩张.
    • IRF5调节参与核糖体生物发生和蛋白质合成的蛋白质,影响瘤细胞转化.

    结论:

    • IRF5在调节乳腺瘤发生和转移方面发挥着至关重要的作用.
    • 恢复IRF5通过调节瘤透淋巴细胞和蛋白质合成来抑制瘤生长和转移.
    • IRF5是改善乳腺癌结局的潜在治疗标.