通过可切割的OFF开关适配器对通用CAR T细胞进行有条件控制
Michael Kvorjak1,2,3, Elisa Ruffo1,2,3, Yaniv Tivon4
1University of Pittsburgh School of Medicine, Department of Surgery, Pittsburgh, PA 15232, USA.
bioRxiv : the preprint server for biology
|June 9, 2023
概括
工程T细胞疗法现在可以精确地使用新的OFF开关适配器控制. 这些适配器增强了通用CAR T细胞的安全性和可编程性,使多个抗原的条件向成为可能.
科学领域:
- 免疫学 免疫学 免疫学
- 生物技术是生物技术.
- 细胞工程 细胞工程
背景情况:
- 工程T细胞疗法提供了革命性的治疗潜力,但面临着难以预测的行为,毒性和药理动力学的挑战.
- 全球仿真抗原受体 (CARs) 通过与联合管理的抗体适配器相互作用,使多抗原向成为可能.
- 需要有条件控制机制来提高T细胞疗法的安全性和可编程性.
结论:
- 关闭开关适配器显著提高了通用CAR T细胞疗法的可编程性和安全性.
- 这种方法提供了一种可靠的方法,用于精确准和条件控制T细胞介导反应.
- 工程适配器有望改善治疗结果并减轻与T细胞疗法相关的风险.
相关概念视频
01:40Cell-mediated Immune Responses
Overview
01:22T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...