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基于OMV的SARS-CoV-2疫苗的免疫性和临床前疗效

Alberto Grandi1,2, Michele Tomasi3, Irfan Ullah4

  • 1Toscana Life Sciences Foundation, Via Fiorentina 1, 53100, Siena, Italy.

Research square
|June 9, 2023
PubMed
概括

用SARS-CoV-2尖端蛋白碎片设计的外膜囊泡 (OMV) 产生中和抗体并保护小鼠免受感染. 这些基于OMV的疫苗显示出对包括Omicron在内的多种变体的潜在作用.

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Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...