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Updated: Jul 27, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Setdb1 - 损失会诱导I型干扰素和黑色素瘤的免疫清除

Meaghan K McGeary, William Damsky, Andrew Daniels

    bioRxiv : the preprint server for biology
    |June 9, 2023
    PubMed
    概括

    黑色素瘤中Setdb1的损失增加了瘤免疫性,并通过激活内源逆转录病毒并触发干扰素信号来促进CD8+T细胞介导的清除. 这凸显了Setdb1作为黑色素瘤治疗的潜在治疗点.

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