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Updated: Jul 27, 2025

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蛋白质纳米颗粒上的抗原间距会影响抗体对疫苗接种的反应

Daniel Ellis1,2,3,4, Annie Dosey1,2,4, Seyhan Boyoglu-Barnum5

  • 1Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.

bioRxiv : the preprint server for biology
|June 9, 2023
PubMed
概括

设计纳米粒子疫苗,使用紧密间隔的流感血质素 (HA) 头抗原,提高了抗体的强度和宽度. 这种新的平台推进了针对流感和其他病毒威胁的基于结构的疫苗设计.

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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