在叶中非典型的连接体拓和信号流
Ke Xie1, Jessica Royer1,2, Sara Larivière1
1Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
bioRxiv : the preprint server for biology
|June 9, 2023
概括
叶 (TLE) 导致大脑网络在海马体之外发生广泛的变化,影响认知. 这些功能性大脑变化与TLE患者的微观结构白质变化和记忆缺陷有关.
科学领域:
- 神经科学是一个神经科学.
- 发病学 (Epileptology) 是一个专业的学科.
- 认知神经学 认知神经学
背景情况:
- 叶 (TLE) 是一种常见的,耐药性,其特征是海马病理.
- 新出现的证据表明,TLE影响大脑网络超出了半时区域,影响认知.
- 了解TLE中的宏观大脑变化对于理解其全部影响至关重要.
研究的目的:
- 为了研究在TLE中的宏观功能性大脑重组.
- 探索这些功能变化的结构基础.
- 检查TLE中大脑变化和认知缺陷之间的关联.
主要方法:
- 多模式3TMRI用于95名耐药TLE患者和95名对照患者.
- 连接ome缩小维度和生成模型评估了功能拓和有效连接.
- 分析了白质的微观结构完整性.
主要成果:
- 患有TLE的患者表现出不典型的功能拓,感觉/运动和跨模网络之间的差异化减少.
- 变化突出在时和腹中前额皮层,显示减少层次流动.
- 这些功能变化与表面白质的微观结构变化有关,而不是灰质缩.
- 功能障碍与记忆障碍相关的程度.
结论:
- TLE涉及宏观的功能重组和大脑网络的不平衡.
- 微观结构的白质变化,而不是皮质缩,介导这些功能变化.
- 在TLE中观察到的功能和结构性大脑变化直接与认知功能障碍,特别是记忆障碍有关.
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