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开发基于Cas13a的测试,用于测试

Lao-Tzu Allan-Blitz1,2,3, Palak Shah2,3, Gordon Adams2,3

  • 1Division of Global Health Equity: Department of Medicine, Brigham and Women's Hospital, Boston, MA.

medRxiv : the preprint server for health sciences
|June 9, 2023
PubMed
概括

新的基于CRISPR的SHERLOCK测试可以检测尼塞利亚淋病并预测对西普洛素的耐药性. 这为性传播感染提供了一个低成本的诊断工具,特别是在资源有限的环境中.

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相关概念视频

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
In vitro Mutagenesis01:16

In vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.