年轻人糖尿病类型的不准确诊断:患病率,特征和影响
Mustafa Tosur1, Xiaofan Huang2, Audrey S Inglis2
1Baylor College of Medicine, Texas Children's Hospital.
Research square
|June 9, 2023
概括
在年轻人中准确分类糖尿病是具有挑战性的. 超过6%的不同儿科患者在诊断时有不准确的糖尿病类型或后来修订,影响了管理.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病研究研究 糖尿病研究
背景情况:
- 在诊断时准确的糖尿病分类对于有效的儿科糖尿病管理至关重要.
- 糖尿病类型之间的临床特征重叠使青少年的诊断复杂化.
- 本研究涉及儿童和青少年未知或修订型糖尿病的流行率和特征.
研究的目的:
- 确定患有未知或修订型糖尿病的年轻人患病率和特征.
- 为了比较患者的人口统计和与不确定的诊断相关的临床因素.
- 评估诊断不确定性对糖尿病管理的影响,包括技术使用.
主要方法:
- 对2073名患有新发糖尿病的年轻人的回顾性分析.
- 基于儿科内分泌学家诊断的未知与已知的糖尿病类型患者的比较.
- 在诊断后≥3年内对分类变化的纵向子队列分析 (n=1019).
- 对混因素进行统计调整,以确定相关因素.
主要成果:
- 糖尿病类型最初在3%的年轻人中是未知的,与年龄较大,阴性IA-2自身抗体,较低的C-和缺乏糖尿病酸性脂肪酸症有关.
- 糖尿病分类在纵向子队列中的3.4%发生变化,没有与特定特征相关联.
- 未知和修订的糖尿病类型都与减少连续使用血糖监测器有关.
结论:
- 大约6.5%的种族/种族多样化的年轻人在诊断时或随访期间经历了不准确的糖尿病分类.
- 准确及时诊断儿科糖尿病类型仍然是一个重大的临床挑战.
- 需要进一步的研究来提高儿科糖尿病类型的诊断准确性.
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