用D-来增强精神分裂症患者的学习与听觉和前部生成的生物标志物有关:一项随机,双盲,安慰剂控制的随机研究
Viraj Govani, Adithya Shastry, Daniel Iosifescu
1Nathan Kline Institute.
Research square
|June 9, 2023
概括
与听觉补救 (AudRem) 结合的N-甲基-D-酸盐类型谷氨酸受体 (NMDAR) 激素d-serine改善了精神分裂症患者的前脑活动. 这表明,除了听觉处理之外,潜在的通用认知益处.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 精神分裂症会损害听觉认知,涉及复杂的大脑网络.
- 以前的研究表明,d-serine和听觉修复 (AudRem) 改善了听觉可塑性和不匹配负面性.
- 这项研究研究了一般化效应和听觉可塑性机制的正面脑电图 (EEG) 结果.
结论:
- 在精神分裂症患者中,d-Serine加AudRem对改善前脑功能生物标志物显示出希望.
- 治疗对前额活动的影响似乎独立于听力可塑性改善.
- 需要进一步的研究来确定这种组合是否足以进行认知补救,或者是否需要额外的前部向干预.
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