在阿尔茨海默氏病进展中的神经生理学轨迹
Kiwamu Kudo1,2, Kamalini G Ranasinghe3, Hirofumi Morise1,2
1Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, 94143, USA.
bioRxiv : the preprint server for biology
|June 9, 2023
概括
神经同步变化,特别是α和β频段的减少,在阿尔茨海默病 (AD) 进展的早期出现,先于神经退行和认知衰退. 这些大脑振荡的变化为AD病理生理学提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
背景情况:
- 阿尔茨海默病 (AD) 涉及粉样β和病理,导致突触功能障碍,神经退行和认知能力下降.
- 在阿尔茨海默病中观察到神经振荡的改变,但它们的进展和与疾病严重程度的关系仍然不清楚.
结论:
- 神经元同步的频率特定变化是阿尔茨海默病病理生理学的早期指标.
- 在AD的过程中,异常的神经同步逐渐发展.
- 涉及多个大脑区域的连接指标对阿尔茨海默氏症早期功能缺陷敏感.
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