在VTA多巴胺神经元中,食物和社会刺激的重叠表示
Lindsay Willmore1, Adelaide R Minerva1, Ben Engelhard1,2
1Princeton Neuroscience Institute, Princeton University, Princeton NJ 08544 USA.
bioRxiv : the preprint server for biology
|June 9, 2023
概括
腹部体区域多巴胺神经元 (VTA DA) 激发诸如饮食和社交等行为. 这项研究表明,相同的VTA DA神经元对食物和社交线索都有反应,这表明了动机的共同神经基础.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 行为科学 行为科学
背景情况:
- 腹膜区域 (VTA DA) 的多巴胺神经元对于激励至关重要,对各种刺激做出反应.
- 目前尚不清楚不同或重叠的VTA DA神经元群是否编码不同奖励的动机,例如食物和社交互动.
研究的目的:
- 调查相同的VTA DA神经元是否编码了食物和社会动机.
- 探索生理状态 (饥饿) 和经验 (社会互动) 如何调节这些神经元反应.
主要方法:
- 在小鼠中利用双光子成像来监测食物和社会刺激呈现期间的VTA DA神经元活动.
- 进行单核RNA测序以分析单个VTA DA神经元内的基因表达.
主要成果:
- 在对食物和社会刺激都有反应的VTA DA神经元群体中发现了显著的重叠.
- 观察到,饥饿和之前的社交经验增加了神经元对这两种刺激的反应比例.
- 在单个VTA DA神经元中确定了与养和社会激素相关的基因的共同表达.
结论:
- 这些发现表明,VTA DA神经元的重叠群体参与了食物和社会动机.
- 这些结果表明,一种共同的神经机制是激发行为不同形式的基础.
- 调节一个刺激的动机可以通过这些重叠的神经元群体影响对其他刺激的反应.
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