细胞启动因子3b调节乳腺癌的发展和进展
Yanhui Li1, Jianhua Zhao2, Zhikun Yuan3
1Department of Pathology, Shijie Hospital Shijie Town, Dongguan, Guangdong, China.
American journal of cancer research
|June 9, 2023
概括
欧核细胞启动因子3亚单元B (eIF3b) 的升级促进乳腺癌的生长和转移. 沉默eIF3b会抑制瘤的发展和扩散,这表明eIF3b是乳腺癌的潜在治疗点.
科学领域:
- 分子瘤学分子瘤学
- 癌症生物学 癌症生物学
- 基因规则 基因规则
背景情况:
- 乳腺癌瘤发生涉及复杂的基因表达变化.
- 专注于转录调节,但翻译控制也至关重要.
- 细胞启动因子 (eIFs) 的失调与各种癌症有关.
研究的目的:
- 为了调查真核细胞启动因子3B (eIF3b) 在乳腺癌中的作用.
- 确定eIF3b表达和乳腺癌进展之间的关系.
- 探索eIF3b作为治疗点的潜力.
主要方法:
- 在乳腺癌细胞系和组织中检查了eIF3b的表达.
- 与瘤阶段和转移相关的eIF3b水平.
- 进行了体外淘汰和过度表达的研究.
- 使用异种移植小鼠模型进行体内评估.
- 调查了Wnt/β-catenin通路. 这是一个很好的例子.
主要成果:
- 在乳腺癌细胞和组织中,eIF3b被上调,与晚期和淋巴结转移相关.
- eIF3b knockdown 抑制了细胞的增殖,迁移和入侵.
- 过度表达eIF3b增强了这些恶性表型.
- 在体内,eIF3b沉默抑制了瘤生长和肺转移.
- eIF3b下调调节了Wnt/β-catenin通路的调节.
结论:
- eIF3b在乳腺癌瘤发生,扩散,入侵和转移方面发挥着重要作用.
- eIF3b通过调节Wnt/β-catenin通路而起作用.
- eIF3b代表了乳腺癌治疗的潜在治疗标.
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