肠道微生物群减少了由慢性不可预测的轻度压力引起的炎症,通过影响NLRP3炎症酶
Li Huang1,2, Zewei Ma1,2, Xiaolei Ze3
1Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.
Frontiers in cellular and infection microbiology
|June 9, 2023
概括
肠道微生物群的改变与抑郁症有关. 益生菌干预可以恢复肠道平衡,减少炎症,并抑制NLRP3炎症酶激活,为抑郁症提供新的治疗途径.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群失生症与抑郁症的发病有关.
- 连接肠道微生物群与抑郁症的确切机制在很大程度上是未知的.
- NLRP3炎症酶激活是关键的炎症途径.
研究的目的:
- 为了研究肠道微生物群和NLRP3炎症酶激活在慢性不可预测的轻度压力 (CUMS) 下之间的关系.
- 阐明肠道微生物群在CUMS诱导的类似抑郁症的行为中的作用.
- 探索益生菌在调节肠道微生物群和炎症方面的治疗潜力.
主要方法:
- 慢性不可预测的轻度压力 (CUMS) 模型在老鼠中.
- 从CUMS大鼠移植便微生物群 (FMT) 到用抗生素治疗的老鼠.
- 测量NLRP3炎症组分 (NLRP3,Caspase-1,ASC),炎症细胞因子和紧密结合蛋白 (Occludin,ZO-1) 的测量.
- 向CUMS治疗的老鼠给予益生菌.
主要成果:
- CUMS显著增加了NLRP3炎症酶激活和炎症标记物,同时降低了大脑和结肠中的紧结蛋白.
- 从CUMS小鼠到接受抗生素治疗的小鼠的FMT引起了类似的变化,表明微生物群驱动的效应.
- 益生菌治疗逆转了CUMS诱导的微生物群变化,减少了NLRP3炎症酶激活,并减轻了炎症.
结论:
- 由CUMS引起的类似抑郁症的行为与肠道微生物群失调,肠道屏障完整性受损和NLRP3炎症酶激活有关.
- 通过益生菌调节肠道微生物组成可以改善炎症并抑制NLRP3炎症酶激活.
- 准肠道微生物群是抑郁症的一种有前途的治疗策略.
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