具有不同精液异常的患者的精液,肠道和尿液微生物群的表征
Tingshuai Cao1,2, Shangren Wang1, Yang Pan1
1Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.
Frontiers in microbiology
|June 9, 2023
概括
男性不孕症与肠道,尿液和精液细菌的变化有关. 这项研究确定了潜在的益生菌,如Collinsella和Lactobacillus,以及诸如Bacteroides和Staphylococcus等病原体,为新的诊断和治疗策略铺平了道路.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 胃肠病学 胃肠病学
背景情况:
- 全球精液质量下降导致男性不孕率上升.
- 了解微生物群在男性生殖健康中的作用至关重要.
研究的目的:
- 分析有异常精液参数的个体的肠道,精液和尿液微生物群.
- 识别可能影响精液质量的益生菌和病原细菌.
- 探索男性不孕症的新诊断和治疗方法.
主要方法:
- 招募对照组和患有不同精液异常的患者组 (精髓缩症,精髓缩症,精髓缩症,精髓缩症,精液超粘度).
- 使用16S核糖体RNA基因测序对肠道,精液和尿液微生物群的分析.
- 对微生物多样性 (α-多样性和β-多样性) 和跨群体的丰度进行比较分析.
主要成果:
- 在健康个体和精液异常的个体之间观察到肠道,尿液和精液微生物群组成和多样性的显著差异.
- 在特定的患者群体中注意到肠道Collinsella,Bifidobacterium和Blautia的丰度减少.
- 在某些异常的精液参数组中发现了肠道细菌和精液葡萄球菌的丰度增加.
- 在患有寡精和精液度过高的患者中观察到尿液中乳酸菌的丰度下降.
结论:
- 这项研究提供了一个综合性比较的生殖尿道和肠道微生物群在男性和没有异常的精液参数.
- 鉴定了与精液质量相关的潜在益生菌 (科林塞拉,比菲多细菌,布劳蒂亚,乳杆菌) 和病原体 (细菌菌,葡萄球菌).
- 建立了基于微生物群分析的男性不孕症新型诊断和治疗策略的基础.
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