追踪B型肝炎病毒基因型H的进化史 墨西哥特有的H型肝炎病毒的进化史
Alexis Jose-Abrego1,2, Sonia Roman1,2, Saul Laguna-Meraz1,2,3
1Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco, Mexico.
Frontiers in microbiology
|June 9, 2023
概括
墨西哥的乙型肝炎病毒 (HBV) 基因型H年龄估计为2070.9年,起源于基因型F.这项研究揭示了自HBV基因型H出现以来,HBV基因型H内的四个主要多元化事件.
科学领域:
- 病毒学 病毒学
- 进化生物学 进化生物学
- 分子流行病学分子流行病学
背景情况:
- 乙型肝炎病毒 (HBV) 是一个全球性的健康问题,有十种基因型 (A-J).
- 甲型HBV基因型H在墨西哥普遍存在,特别是在土著人口中,这表明流行.
- 墨西哥HBV H型基因组的进化史和确切年龄在很大程度上是未知的.
研究的目的:
- 通过分子约会,确定墨西哥的乙型肝炎病毒 (HBV) 基因型H的进化年龄.
- 为了研究HBV基因型H及其最亲近的亲属,基因型F之间的分歧时间.
- 在墨西哥的HBV H型基因组中确定主要的多样化事件.
主要方法:
- 对92个HBV逆转录酶 (RT) 基因序列的分析 (~1,251 bp).
- 包括48个H型基因组序列,43个F型基因组序列,以及最古老的美国HBV序列作为根.
- 使用贝叶斯天际线进化分析计算最近的共同祖先 (TMRCA) 的时间.
主要成果:
- 墨西哥HBV H型基因组的TMRCA估计在现在 (YBP) 之前的2070.9年.
- 在基因型H内确定了四个不同的多样化事件 (H1,H2,H3,H4),TMRCAs范围从949.6到1230.5 YBP.
- 据估计,HBV H 基因型与 F 基因型差异约为 8140.8 YBP.
结论:
- 在墨西哥,HBV H型基因型的估计年龄约为2070.9年.
- 在墨西哥出现HBV H基因型后,至少发生了四次重大多样化事件.
- 这项研究为墨西哥人口中HBV H基因型的进化时间表和多样化提供了关键的见解.
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