废水处理厂是ESCAPE病原体的"逃生门"
Luminita Gabriela Marutescu1,2, Marcela Popa2, Irina Gheorghe-Barbu1,2
1Department of Microbiology and Immunology, Faculty of Biology, Research Institute of the University of Bucharest, University of Bucharest, Bucharest, Romania.
Frontiers in microbiology
|June 9, 2023
概括
污水处理厂 (WWTP) 是抗生素耐药细菌 (ARB) 和抗生素耐药基因 (ARG) 的关键储存库. 监测WWTP对于控制ESCAPE细菌等耐药病原体的传播和保护公共健康至关重要.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生 公共卫生
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 滥用抗生素加快了耐药性,威胁到现代医学.
- 环境,特别是废水,充当了抗生素耐药性演变和传播的储.
- 污水处理厂 (WWTP) 是管理抗生素耐药病原体的关键控制点.
研究的目的:
- 审查ESCAPE病原体的存在和命运 (菌杆菌,黄金菌,困难菌,宝曼菌, Pseudomonas aeruginosa 和 Enterobacteriaceae spp.) 在WWTP中.
- 评估WWTPs在抗生素耐药细菌 (ARB) 和抗生素耐药基因 (ARG) 的传播中的作用.
- 强调需要监测WWTP在消除ARB和ARG方面的效率.
主要方法:
- 文献综述侧重于分析WWTP中的ESCAPE病原体的研究.
- 分析全基因组测序数据,以了解克隆关系和耐药性决定因素.
- 评估影响废水处理过程中ARB和ARG去除的因素.
主要成果:
- 所有ESCAPE病原体物种,包括高风险克隆物种,都被检测到废水中.
- 存在对最后手段抗生素 (碳烯,胆固醇) 和多药耐药性平台的耐药性决定因素.
- 医院的废水有助于格拉姆阴性ESCAPE物种的传播;金黄色菌和肠球菌显示了WWTP中毒性和耐药性基因的丰富.
结论:
- 水水区是ARB和ARG的重要储库和潜在传播途径.
- 有效的WWTP监测和治疗策略对于减轻抗生素耐药性的环境和公共卫生威胁至关重要.
- 开发WWTP废水的质量标准是必要的,以加强其作为抗菌素耐药性 (AMR) 的障碍者的作用.
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