刺激性肠综合征和与酒精使用障碍相关的焦虑并发症的模型
Katsiaryna Vashkevich1, Kathryn Janiuk1, Nasim Maleki1,2
1Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Frontiers in medicine
|June 9, 2023
概括
刺激性肠综合征 (IBS) 与焦虑障碍的并发症在患有酒精使用障碍 (AUD) 的慢性疼痛患者中较高. 解决胃肠道问题可能会改善AUD和焦虑治疗结果.
科学领域:
- 神经胃肠病学 神经胃肠病学
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
背景情况:
- 血清素主要在胃肠道 (GI) 中合成,对情绪调节至关重要.
- 焦虑症与低血清激素水平有关,并且经常伴随慢性疼痛.
- 酒精使用障碍 (AUD) 可以加剧胃肠道问题,原因是酒精对胃肠道粘膜的破坏性影响.
研究的目的:
- 为了研究慢性疼痛患者的刺激性肠综合征 (IBS) 和焦虑障碍之间的关联.
- 为了确定酒精使用障碍 (AUD) 的病史是否会改变慢性疼痛患者的IBS-焦虑症并发症.
主要方法:
- 在252名慢性疼痛患者的横截面研究中.
- 刺激性肠综合征 (IBS) 和焦虑症患病率的评估.
- 对伴随性酒精使用障碍 (AUD) 对IBS和焦虑伴随性影响的分析.
主要成果:
- 慢性疼痛患者与没有AUD病史之间的IBS患病率没有显著差异.
- 患有AUD病史的慢性疼痛患者显示,IBS与焦虑障碍的并发症明显更高.
- 这些发现表明,在慢性疼痛患者中,一种独特的途径将胃肠道功能障碍,焦虑和AUD联系在一起.
结论:
- 焦虑障碍与IBS的并发症在患有AUD的慢性疼痛患者中被放大.
- 与慢性饮酒相关的胃肠道问题可能在这种扩大并发症中发挥着中心作用.
- 针对患有AUD和焦虑障碍的患者的胃肠道问题,可以提高治疗效率和从问题饮酒中恢复.
相关概念视频
01:17Irritable Bowel Syndrome I: Introduction
327
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
327
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
199
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
199
01:30Irritable Bowel Syndrome III: Medical and Nursing Management
254
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
254
01:17Drugs for Treatment of Diarrhea-Predominant IBS
219
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
219
01:30Generalized Anxiety Disorder
169
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
169
01:17Chronic Bowel Disorders: Introduction
492
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
492