晚期HCC与放大介细胞上皮转变因子受体对萨沃利提尼布反应良好:一个病例报告
Ningning Yan1, Ziheng Zhang1, Sanxing Guo1
1Department of Medical Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in medicine
|June 9, 2023
概括
萨沃利提尼布在使用MET放大后的晚期肝细胞癌 (HCC) 中表现有前途. 这种MET-TKI在初始治疗失败后提供了比标准治疗更好的无进展生存期.
科学领域:
- 肝细胞癌研究 肝细胞癌研究
- 瘤学 药物开发 药物开发
- 分子向疗法分子向疗法
背景情况:
- 目前用于肝细胞癌 (HCC) 的治疗方法,包括免疫检查点抑制剂 (ICI) 和氨酸激酶抑制剂 (TKI),对应答率和无进展生存率 (PFS) 有限制.
- 介质细胞上皮质过渡因子受体 (MET) 氨酸激酶抑制剂 (MET-TKIs) 已在MET改变的固体瘤中显示出有效性,但它们在MET增强的HCC中的作用尚不清楚.
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