在资源较少的环境中治疗原发性阴道黑色素瘤的多模式治疗:一个案例报告
Ramesh Shrestha1, Karun Devkota2, Baburam Dixit Thapa1
1Department of Obstetrics and Gynaecology, B. P. Koirala Institute of Health Sciences, Dharan, Nepal.
Gynecologic oncology reports
|June 9, 2023
概括
一个罕见的阴道黑色素瘤病例在一个32岁的女性接受了手术,放射治疗和Pembrolizumab的治疗. 患者实现了9个月的无进展生存期,仍然没有疾病.
科学领域:
- 妇科瘤学 妇科瘤学
- 皮肤病学 皮肤病学
- 手术瘤学手术瘤学
背景情况:
- 初级性阴道黑色素瘤是一种罕见的,攻击性的恶性瘤,占所有黑色素瘤的1-2%和阴道癌症的5-10%.
- 这份报告详细介绍了一个年轻女性患者的原发性阴道黑色素瘤的独特病例.
研究的目的:
- 为了介绍一种原发性阴道黑色素瘤的案例研究.
- 为了突出罕见的妇科恶性瘤的治疗和结果.
主要方法:
- 一个32岁的女性在小唇部出现了2厘米的生长.
- 治疗涉及到广泛的局部切除,尿道切除,双边关节剖析,辅助放射治疗和布利祖马布治疗.
主要成果:
- 最终的组织病理学证实了阴道恶性黑色素瘤,15个关节中的1个受到影响;边缘清晰.
- 患者的最后阶段是T4bN1aM0 (AJCC) 和IIIC (FIGO).
- 经过17个Pembrolizumab循环后,该患者实现了9个月的无进展生存,并且在临床和放射学上仍然没有疾病.
结论:
- 包括免疫疗法在内的多种模式治疗可以有效治疗晚期初级膜黑色素瘤.
- 这一案例表明,对于一种罕见且具有攻击性的癌症,辅助布洛利祖马布治疗具有积极的结果.
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