一种基于表面活性剂的冷化素配方,具有改善的物理特性和溶解,可用于口服
Helmy Yusuf1, Orchidea Meidy Nurintan Savitri1, Riesta Primaharinastiti1
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Jl. Mulyorejo, Surabaya 60115, Indonesia.
概括
这项研究通过使用Poloxamer创建固体分散 (SD) 来增强口服Rutin (RUT). 开发的RUT/SD配方显著增加了Rutin.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物化学 生物化学
背景情况:
- 素 (RUT) 是一种类黄素,具有治疗潜力,但其口服生物可用性不佳.
- 较差的水溶性和透性限制了Rutin的临床应用.
研究的目的:
- 通过开发固体分散 (SD) 配方来增强Rutin的口服.
- 用Poloxamer 407和188.8来提高Rutin的溶解性和溶解率,使用Poloxamer 407和188.
- 描述Rutin载荷固体分散物的物理性质和溶解行为.
主要方法:
- 使用Poloxamer (POL) 407和188. 制备了鲁丁 (RUT) 的固体分散剂 (SD).
- 描述涉及偏振显微镜,差异热分析 (DTA),X射线衍光测量 (XRD) 和扫描电子显微镜 (SEM).
- 溶解研究是使用装置进行的,并通过紫外线光谱仪进行分析.
主要成果:
- 极化显微镜显示了鲁与Poloxamer矩阵的混合性.
- SEM揭示了不同的形态,从多孔表面到更光滑的表面,这取决于鲁的度.
- XRD和DTA显示,Rutin存在于部分无形状态,随着药物负载的增加而增加.
- 溶解率显著增加,SD配方的溶解率在一个小时内达到94-100%,而纯Rutin的溶解率为<35%.
结论:
- 该研究成功地改善了鲁固体分散物的物理特性.
- 开发的Rutin/SD配方表现出增强的溶解性和溶解性.
- 这些发现支持Rutin/SD在未来口服药物递送应用中的潜力.
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