外周和中央免疫标志物之间的相互作用在临床上具有精神病的高风险
Kankana Nisha Aji1,2,3, Sina Hafizi2,4, Tania Da Silva2,5
1Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.
Brain, behavior, & immunity - health
|June 9, 2023
概括
神经炎症可能是精神分裂症的前身. 这项研究发现,外周炎症标志物与临床精神病高风险患者的症状相关,但脑炎症标志物 (TSPO) 根据炎症水平没有差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 神经炎症与精神分裂症的发展有关.
- 有限的研究存在于周围炎症和精神病前兆中的大脑标志物.
- 线粒体18kDa转位蛋白 (TSPO) 是神经炎症的标志物.
研究的目的:
- 为了比较临床高风险 (CHR) 精神病和健康对照个体之间的外周炎症标志物.
- 为了研究大脑TSPO水平和CHR组中的外周炎症标志物之间的关联.
- 为了探索大脑TSPO表达的预测因素.
主要方法:
- 结构性大脑MRI和[18F]FEPPA PET扫描对38名CHR患者和20名健康对照进行了.
- 血清样本被分析为周围炎症标记物,包括C反应蛋白 (CRP) 和白细胞间蛋白 (ILs).
- 参与者根据标志物水平被分为炎症集群.
主要成果:
- 增加的IL-8水平与一般症状严重程度有积极的相关性,并且在CHR组中显示出无动于衷的趋势.
- 确定了明显的炎症集群 (IL-1β,IL-2,IFN-γ),并且可以在CHR和对照组之间进行比较.
- CRP,IL-1β,TNF-α和IFN-γ水平独立预测大脑TSPO表达.
结论:
- 周围炎症标志物与患有精神病临床高风险个体的症状相关.
- 大脑TSPO水平并没有根据这个队列中的炎症不同.
- 炎症聚类是理解精神病中脑外炎相互作用的潜在策略.
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