COVID-19的神经类型:风险因素和康复结果
Divya Prabhakaran1,2, Gregory S Day3, Bala Munipalli4
1Mayo Clinic, Center for Individualized Medicine, Jacksonville, FL, USA.
Brain, behavior, & immunity - health
|June 9, 2023
概括
后COVID-19的神经并发症表现在不同的群体,而不是单一的综合征. 识别这些COVID-19神经类型有助于针对性治疗和理解长期的认知影响.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
背景情况:
- 持续的神经认知和神经精神问题与COVID-19有关.
- 这些COVID-19后表现的性质尚不清楚,有关统一综合征与明显的神经类型的疑问仍然存在.
研究的目的:
- 在SARS-CoV-2感染后,调查和识别不同的神经心理特征 (神经类型).
- 探索与这些已识别的神经类型相关的不同风险因素和恢复结果.
主要方法:
- 利用对205名急性后COVID-19患者客观和主观措施的无监督机器学习集群分析.
- 输入特征包括一系列认知和主观评估,以识别不同的患者群.
主要成果:
- 确定了三种不同的COVID-19后神经类型:"正常认知" (69%),"记忆速度受损" (16%) 和"dysexecutive" (15%).
- 接种疫苗与"正常认知"组相关;阿诺斯米亚和严重感染与"记忆速度受损";邻里贫困和肥胖与"dysexecutive".
- 恢复结果各不相同:"正常认知"提高了口头记忆/精神运动速度",dysexecutive"提高了认知灵活性,而"记忆速度受损"没有客观改善.
结论:
- 后急性COVID-19呈现为多个不同的神经类型,而不是单一的综合征.
- 这些神经类型具有不同的病因路径和恢复轨迹.
- 了解这些不同的形状对于开发长期COVID神经效应的表型特异性治疗策略至关重要.
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