骨质细胞及其骨质结晶生长潜力
Aseel Marahleh1,2, Hideki Kitaura2, Fumitoshi Ohori2
1Frontier Research Institute for Interdisciplinary Sciences (FRIS), Tohoku University, Sendai, Japan.
Frontiers in endocrinology
|June 9, 2023
概括
骨细胞,关键的骨细胞,通过多种途径启动骨质细胞形成来调节骨重塑. 然而,目前的动物模型限制了关于它们作为这个过程的主管管弦乐师的角色的最终结论.
科学领域:
- 骨生物学 骨生物学
- 细胞生理学 细胞生理学
- 生物矿物化 生物矿物化
背景情况:
- 骨架提供结构性支持和保护,作为一种重要的矿物质和荷尔蒙储存器,用于恒温.
- 骨重塑,一个持续的吸收和形成过程,对于骨的完整性和生物体的生存至关重要.
- 骨质细胞,骨质母细胞和骨质细胞是骨重塑中的关键细胞参与者,骨质细胞因其机械传感作用而得到认可.
研究的目的:
- 为骨细胞生物学提供全面的综述,包括骨细胞的发育和骨细胞缺陷运河网络 (LCN).
- 探索骨质细胞在调节骨质细胞形成中的作用,特别是在无骨细胞性骨环境中.
- 根据现有研究,批判性地评估目前对骨细胞作为"骨重塑的管弦乐器"的理解.
主要方法:
- 对关于骨细胞生成,骨细胞形态学和LCN的现有文献的审查.
- 对转录基因数据的分析,以了解骨细胞基因表达.
- 检查各种模型中研究骨质细胞介导骨质结晶发生的研究.
主要成果:
- 骨细胞通过几个冗余机制参与骨质细胞的形成.
- 骨质细胞缺陷运河网络 (LCN) 是一个复杂的结构,对细胞间通信至关重要.
- 转录组分析揭示了对骨细胞功能和调节的新见解.
- 目前用于研究骨细胞生物学的动物模型不是骨细胞特异性的,限制了最终的结论.
结论:
- 骨细胞拥有多种途径来启动骨质细胞形成.
- 骨细胞在骨重塑中的精确"编排"作用需要使用更具体的模型进行进一步的研究.
- 由于潜在的混因素,非特异性动物模型的发现应谨慎解释.
相关概念视频
Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
Bone Cells and Tissue
4.8K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
4.8K
Bone Remodeling
38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
Hormones and Bone Tissue
2.8K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.8K
Bone as Supporting Connective Tissue
3.6K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
3.6K
The Bone Matrix
3.3K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
3.3K


