口腔白血病中的化疗预防:挑战和当前景观
Victor de Mello Palma1, Natalia Koerich Laureano1, Luiza Abrahão Frank2
1Oral Medicine Department, School of Dentistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Frontiers in oral health
|June 9, 2023
概括
化疗预防剂在预防口腔白血病的进展方面表现有前途,这是口腔癌的前体. 需要进一步的研究来确定治疗反应的有效药物和生物标志物.
科学领域:
- 口服药是一种口服药.
- 在瘤学瘤学.
- 致癌性研究的研究.
背景情况:
- 口腔潜在恶性疾病 (OPMDs) 可以发展为口腔癌.
- 口腔白血病 (OL) 是一种常见的OPMD,具有显著的恶性转变率 (9.8%).
- 目前对OL的手术治疗在预防复发和恶性转变方面有效性有限.
研究的目的:
- 对口腔白血病的化学预防药物的人类研究进行审查.
- 评估这些药物的有效性,以防止OL的进展.
- 为未来的口腔癌化学预防研究提供指导.
主要方法:
- 人类临床研究的系统审查.
- 系统性和局部化疗预防剂的识别和分类.
- 对药物的疗效现有证据的分析.
主要成果:
- 许多系统性药物 (例如,维生素A,利科,黄素,甲胺) 和局部药物 (例如,白素,异氨酸) 已被研究.
- 目前支持测试化学预防剂有效性的证据有限.
- 在预防复发和恶性转变方面,外科切除OL的疗效受到限制.
结论:
- 化疗预防提供了一种有前途的策略,可以抑制口腔致癌并减少口腔癌的发生率.
- 识别新型化学预防剂和预测生物标志物对于推进OL管理至关重要.
- 未来的研究应该专注于开发针对口腔白血病的有针对性和有效的化学预防疗法.
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