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暴露于电离辐射和痴呆风险:系统性审查和元分析
Tanvi Srivastava1, Ekaterina Chirikova1, Sapriya Birk2
1Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, San Francisco, California 94143.
Radiation research
|June 9, 2023
概括
暴露于电离辐射可能会增加痴呆症风险. 一项元分析发现,随着100mSv辐射暴露,痴呆的风险增加了11%,帕金森病的风险增加了12%. 需要进一步的研究.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 流行病学 流行病学
背景情况:
- 全球痴呆症发病率随着预期寿命的增加而上升.
- 电离辐射暴露在医疗,职业和环境环境中很常见.
- 了解辐射与痴呆的联系,包括阿尔茨海默氏症和帕金森病,至关重要,特别是在长期太空旅行中.
研究的目的:
- 系统地审查和分析有关电离辐射暴露与痴呆风险之间的关联的现有文献.
- 评估出版偏见并探索研究辐射暴露和痴呆症 (包括阿尔茨海默氏症和帕金森病) 的研究中的异质性.
主要方法:
- 按照PRISMA指南,对PubMed (2001-2022) 的系统文献搜索.
- 包括18项涵盖五个暴露人群的研究:原子弹幸存者,放射治疗患者,职业暴露工人,环境暴露和诊断成像.
- 对已公布的痴呆症及其亚型 (阿尔茨海默病,帕金森病) 风险估计的随机效应元分析.
主要成果:
- 观察到所有痴呆症亚型的1.11 (95% CI:1.04,1.18) 的概括相对风险,将接受100mSv辐射的人与没有暴露的人进行比较.
- 在帕金森病发病率和死亡率方面发现了1.12 (95% CI 1.07,1.17) 的概要相对风险.
- 有证据表明,电离辐射暴露与痴呆症风险增加之间存在统计学上显著的关联.
结论:
- 该研究提供了证据,将电离辐射暴露与痴呆症风险增加联系起来.
- 研究结果表明,辐射与像帕金森氏症这样的神经退行性疾病之间存在潜在的关联.
- 需要进一步的纵向研究,使用可靠的暴露数据和混调整来确认因果关系.
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